Carbon Ion Radiotherapy: Clinical Experiences at National Institute of Radiological Science (NIRS)
نویسندگان
چکیده
منابع مشابه
Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS).
In June 1994, the world's first clinical center offering carbon ion radiotherapy opened at the National Institute of Radiological Science (NIRS), Japan. Among several types of ion species, carbon ions were chosen for cancer therapy because they were judged to have the most optimal properties in terms of superior physical and biological characteristics. As of March 2010, 5,196 patients have been...
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Charged particles can achieve better dose distribution and higher biological effectiveness compared to photon radiotherapy. Carbon ions are considered an optimal candidate for cancer treatment using particles. The National Institute of Radiological Sciences (NIRS) in Chiba, Japan was the first radiotherapy hospital dedicated for carbon ion treatments in the world. Since its establishment in 199...
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Carbon-ion radiotherapy (C-ion RT) possesses physical and biological advantages. It was started at NIRS in 1994 using the Heavy Ion Medical Accelerator in Chiba (HIMAC); since then more than 50 protocol studies have been conducted on almost 4000 patients with a variety of tumors. Clinical experiences have demonstrated that C-ion RT is effective in such regions as the head and neck, skull base, ...
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Radiotherapy using charged and/or high-LET particles has a long history, starting with proton beams. In vitro data clarify that RBE (Relative Biological Effectiveness) increases with LET up to approximately 150 keV/μm for carbon-12 and neon-20 ions. In vivo studies show that tumor control probabilities after single doses of gamma rays shift to higher doses when tumors were irradiated with 5-fra...
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The carbon-ion radiotherapy (RT) with HIMAC has been conducted since 1994, and the accumulated number of patients treated exceeded 7,500 in July 2013. On the basis of the HIMAC experience, NIRS developed a compact carbon-ion RT facility in order to boost the carbon-ion RT in Japan, and a pilot facility of this work was constructed and conducted at the Gunma University. Toward the further develo...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2010
ISSN: 0449-3060,1349-9157
DOI: 10.1269/jrr.10016